shockmesane
Dog Kichi
Sep 14, 2003, 12:10 AM
Post #7 of 34
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Re: [BaoBao] Need help urgently to save a dog
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for those who are interested to know, here's the story, in least technical terms for the average person to understand:
*warning, this can be lengthy*
The main 'ingredient' used ; Newcastle Disease Virus (NDV) Vaccine. NDV is a type of of virus in the same group as Canine Distemper Virus (CDV). They have similar morphology and characteristics. NDV only affects the avian group, not others.
When NDV vaccine is introduced into the donor dog via blood stream, just like any other vaccination done, this would be responded by the immune system to create antibodies. This time around, being identified first time in the body, creates a less specific interferon. Interferons are like messengers, they inform cells in the body that the invader is here. Therefore, the cells will be alerted not to allow these invaders to enter. Without the host (living cells), the virus cannot replicate.
When the serum was separated from other blood components, the introduction of the serum into distemper dogs contains a high dosage of interferons. At this stage, me or the 'founder', can only assume it is interferon. Explanation given later.
When the diseased dog receives the serum, the resulting effect is eliminating the virus in the host. How or what, or when, etc is not known, as loads of money is needed to carry out the research, in which the vet could not obtain and being ridiculed by the board of vets in US as none believes it works.
However, the vet is too devastated that he no longer speak of it, but continued saving distemper dogs in his hospital for decades now. The results ? It's almost always successful, as long as the neuro system is not affected yet. The symptoms of distemper is gone between 12-48 hours post injection. Antibiotics for secondary infections should be continued to prevent bacterias from attacking the dogs.
As mentioned earlier, it was just hypothesised to be interferons, but exactly, what is the key factor is not known. Even interferons are divided into several types. Serum contains many other stuffs contains in blood, and a healthy vaccinated donor is chosen. .
To relate to you on my experience, I have tried all the possible methods to treat my second puppy. including interferons purchased. but this does not work, as it is as general type. Before i managed to try this serum, or the alternative of directly injecting the NDV vaccine directly, my puppy develops neuro symptoms. Too late to do anything.
That is why, I'm very interested to try the alternative method at this moment for distemper dogs. And yes, vaccinated dogs can be infected as well. There has been cases where adult vaccinated dogs are infected, probably from a different strain of virus, possibly transmitted from coyotes or wolfs. This was reported in US.
For owners of distemper survived dogs, this is very lucky, and their immune system reacted fast and strong. especially for those who were vaccinated against distemper.
For those unvaccinated dogs, the most possible reason would be the diseased dog's immune system failed to mount an immune response, like my puppy.
If this realised your conscience of what you could do for your dogs, you can try to consider bringing a donor dog. As stated above, a large mix breed was needed. However, this is because a big amount of blood will be drawn out at once. Medium size can also be used, but much less blood can be withdrawn, as their volume of blood significantly at much smaller volumes than very large breeds.
one dog can only be used one time only. The second time the vaccine is introduced, only antibodies towards newcastle diseases virus is produced, and no longer be able to attack distemper virus.
Until a proper study or research is being carried out to identify and possibly prepared it without a donor dog, this is the best alternative than waiting to see if your dog can survive the disease or end up with another heart broken owner.
Jack
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Need help urgently to save a dog
Kowie, Ah Kow & Whitie 
Hi, 
i never really thought of that phrase, and you made me realised now what the folks were talking about all the time... hahaha. 
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